The programme benefits from the clinical and epidemiological expertise and the renal cell carcinoma samples that are available through International Agency for Research Cancer in Lyon and their collaborators, and the Cancer Research UK Centre in Leeds. These groups provide access to the largest and best-characterised collections for these studies that are available worldwide. The programme draws upon genomic facilities and expertise available at the Centre National de Genotypage (CNG) in Evry, France, the Fondation Jean Dausset CEPH in Paris, France, and the Biotechnology Institute in Moscow, Russia. These institutes have large genotyping and sequencing facilities that will be used in these investigations. The CNG manages the FP6 project READNA on the development of new sequencing technologies which will be brought into CAGEKID as they become deployed.

Data analysis will be performed using tools that have been developed in these laboratories and at the European Bioinformatics Institute (EBI), which is a partner in the proposal. Validated markers have been identified in specific genes, antibodies will be obtained and their tissue distribution studied using the pipeline established for affinity proteomics at the Royal Institute of Technology in Stockholm ( Ethical and societal aspects will be addressed in CAGEKID under the responsibility of A. Cambon-Thomsen (INSERM U 558, Toulouse) who is a member of the ICGC sub-committee dealing with these issues in an international context. Other members of CAGEKID at the IARC (Partner 2), CNG (Partner 10) and CEPH (Partner 1) participate in the scientific steering group and other working groups of the ICGC.


Beneficiary name Beneficiary short name Country
1 CEPH Fondation Jean Dausset CEPH FR
2 IARC International Agency for Research on Cancer FR
3 CU-IHE Charles University of Prague, First Faculty of Medicine, Institute of Hygiene and Epidemiology CZ
4 RCS-CRC Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre and Russian Cancer Society RU
5 EMBL European Molecular Biology Laboratory, European Bioinformatics Institute DE
6 KI Karolinska Institute/ Karolinska University Hospital SW
7 CB Center BioEngineering, Russian Academy of Sciences RU
8 UNIVLEEDS Cancer Research UK Centre, University of Leeds, UK UK
9 KTH Royal Institute of Technology, KTH SW
10 CEA-CNG Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique et aux Energies Alternatives FR
11 INSERM Institut National de la Sante et de la Recheche Medicale FR
12 IMCS Institute of Mathematics and Computer Science LV
13 UU Uppsala University SW
14 KSC Kurchatov Scientific Center RU