Programmes Européens EU PCRD5

European network to develop genetic markers for essential hypertension (EURNETGEN)

• Coordinator

  Contact Person:
  Susan FERGUSON (Mrs)
  Tel: +44-14-13304992
  Fax: +44-14-13302747
  Email: Contact

  Organisation:
  UNIVERSITY OF GLASGOW
  DEPARTMENT OF MEDICINE AND THERAPEUTICS
  University Avenue
  G12 8QQ
  Glasgow
  UNITED KINGDOM

Project description

To develop and evaluate a panel of novel SNPs within 100 candidate genes characterised by a putative pathophysiological link to essential hypertension and/or its complication. These genetic markers will undergo initial evaluation, including the construction of haplotypes and testing for their functional significance, on the existing DNA banks: DZ twins and parents, and nuclear families recruited by EPOGH (European Project On Genes in Hypertension) study.

At the same time, TDT family trios (600) are collected in Glasgow, Paris and Milan. A special emphasis is on uniform high fidelity phenotyping, which is made possible by common standard operating procedures, stringent quality control system and common protocols for data analysis. A central database is being established with the ability to input all phenotypic and genotypic data.

Consortium participants

• QUEEN MARY & WESTFIELD COLLEGE, UNITED KINGDOM
• MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE, GERMANY
• KATHOLIEKE UNIVERSITEIT LEUVEN, BELGIUM
• UNIVERSITA VITA-SALUTE SAN RAFFAELE, ITALY
• INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, FRANCE