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Programmes Européens EU PCRD5

EUROAS European genomic bank and clinical, genetic and immunogenetic database of Ankylosing Spondylitis and the other Spondyarthropathies (EUROAS GENOMIC BANK)

Objectives

To optimise and reinforce existing infrastructure of 6 partner laboratories and 9 clinical centres doing a task force
To harmonise techniques already used (DNA, cell and sera extraction, cell line establishment) and to develop new techniques and standards
To ensure quality control of HLA molecular typing procedures, B27 subtyping, distribution of reference DNA
To provide a repository of Ankylosing Spondylitis (AS) and other Spondyarthropathies (SPA) DNA, cells and sera (thanks to up to 4000 already identified affected families), with accurate clinical status (affected/unaffected, disease severity) allowing to determine susceptibility and severity factors of AS and SPA
To coordinate fine gene mapping studies to identify new susceptibility MHC and non-MHC genes
To supply a centralised database with all clinical and genetic details arisen from these families for the use of researchers
To disseminate after appropriate property protection all anonymised available results