Programmes Européens EU PCRD5

Rodent models for oligogenic human diseases: infrastructure facilitating the progression from genetics to the gene containing the putative aetiological variant & to the functional validation of genes & pathways (INFRAQTL)

• Coordinator

  Organisation:
  MEDICAL RESEARCH COUNCIL
  MAMMALIAN GENETICS UNIT
  Harwell
  OX11 0RD
  DIDCOT, HARWELL, CHILTON
  UNITED KINGDOM

Project description

Genetic studies in rat and mouse models of human disorders have highlighted the complementary inputs provided by the two species in the genetic dissection of complex traits.

In order to take advantage of the access to novel gene functions promised by mouse and rat QTL studies, an innovative infrastructure of both techniques and materials that provide strategic support for QTL research in Europe is prepared. One of the major objectives is to co-ordinate efforts and expertise between mouse and rat geneticists and to develop new infrastructures for QTL mapping, high throughput genotype analysis and expression profiling systems applied to disease gene identification in rodents. This project will lead to the identification of validated genes and pathways for drug discovery.

Participants

• MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V., GERMANY
• UNIVERSITY OF LEICESTER, UNITED KINGDOM
• THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, UNITED KINGDOM
• INSTITUTE OF MOLECULAR GENETICS - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, CZECH REPUBLIC
• CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE, FRANCE