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Programmes Européens EU PCRD5

Optimisation of typing policies for european marrow donors registries: socio-economic evaluation of molecular techniques and recruitment strategies (MADO)

  • Coordinator

    Contact Person:
    Christian BRECHOT (Mr)

    Organisation:
    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    U 558 - EPIDMIOLOGIE ET ANALYSES EN SANT PUBLIQUE : RISQUES, MALADIES CHRONIQUES ET HANDICAPS
    AllTes Jules Guesde 37 FacultT de MTdTcine Purpan
    37073 Toulouse
    FRANCE
Project description

Although 6 million potential donors are registered worldwide, finding a donor compatible for allogenic stem cell graft is hard because of HLA polymorphism. MADO aims at evaluating optimisation of Registries in Europe by increasing the proportion of donors presenting rare HLA combinations to reduce inequality of patients in a cost/effective way. The main concept is an evolving filter to screen potential donors at low cost before full HLA typing for the likely presence of frequent types. The overall expected achievement is a number of well documented possible scenarios to help decision for organisation of coherent strategies of Registry management.

1st axis: Test and evaluation of a possible filter

  1. that would allow to screen potential donors at low cost before full HLA typing for the likely presence of frequent or rare combinations using new markers and new technological approaches
  2. that would be adaptable to the actual contents of Registries as they evolve

2nd axis: Socio-demographic investigation

Analysis of socio-economic characteristics of donors and the ways recruitment are performed in order to give a basis for setting up recruitment strategies allowing to contact a more diversified population possibly including minorities

Participants
  • ADVANCED BIOTECHNOLOGY CENTRE, ITALY
  • UNIVERSIT DE TOULOUSE II - 'LE MIRAIL', FRANCE
  • INTERNATIONAL GENETIC TECHNOLOGIES, FRANCE
  • ITALIAN BONE MARROW DONOR REGISTRY, ITALY
  • GROUPE GREFFE DE MOELLE - FRANCE - TRANSPLANT, FRANCE
  • STICHTING EUROPDONOR FOUNDATION, NETHERLANDS
  • CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE, FRANCE
  • UNIVERSITE DE TOULOUSE 1, SCIENCES SOCIALES, FRANCE
  • LEIDEN UNIVERSITY, NETHERLANDS
  • THE ANTHONY NOLAN BONE MARROW TRUST, UNITED KINGDOM
  • SEMMELWEIS UNIVERSITY, HUNGARY
  • NATIONAL MEDICAL CENTER, HUNGARY