A GABRIEL Consortium Large-Scale Genome-Wide Association Study of Asthma

 

 

 

RESTRICTED

Collaborating Partners

Miriam F. Moffatt, D.Phil.1,2,*, Ivo G. Gut, Ph.D.2,3,*, Florence Demenais, M.D.2,4,5,6,7,*, David P. Strachan, M.D.2,8,9, Emmanuelle Bouzigon, M.D., Ph.D.2,4,5,6,7,  Simon Heath, Ph.D. 3, Ashish Kumar, M.Sc.2,10, Peter Burney, M.D.2,11,12, Debbie Jarvis, M.D.2,11,12, Matthias Wjst, M.D.12,13,14, Manolis Kogevinas, M.D., Ph.D.12,15,16,17,18, Rain Jogi, M.D., Ph.D.12,19, Christer Janson, M.D.12,20,  Karl A. Franklin, M.D., Ph.D.12,21, Ernst Omenaas, M.D., Ph.D.12,22,23, Benedicte Leynaert, Ph.D.12,24,25, Isabelle Pin, M.D.7,9,12,26,27,28, Joachim Heinrich, Ph.D.12,29, Nicole M. Probst-Hensch, Ph.D.2,12,30,31,32,33, Josep M. Anto, M.D., Ph.D.12,15,16,17,34, Jordi Sunyer, M.D., Ph.D.12,15,16,17,34, Jose-Antonio Maldonado, M.D.12,35,36, Jesus Martinez-Moratalla, M.D.12,36, Isabel Urrutia, M.D., Ph.D.12,37, Felix Payo, M.D.12,38, Francine Kauffmann, M.D.2,7,39,40, Marie-Hélène Dizier, Ph.D.2,4,5,6,7, Valérie Siroux, Ph.D.2,7,27, Andrzej Boznanski, M.D., Ph.D.41,42, Charlotte Braun-Fahrländer, M.D.2,30,31,42, Jon Genuneit2,42, 43, Juergen Glas, M.D.42, 44, Elisabeth Horak, M.D.42, 45, Michael Kabesch, M.D.2,42,46, Sreekumar G. Pillai, Ph.D.2,47,48, Peter J. Helms, M.B.B.S., Ph.D.48,49, Karin Carlsen, M.D., Ph.D.48,50, Kai-Håkon Carlsen, M.D., Ph.D. 48,50, Jorrit Gerritsen, M.D., Ph.D.48,51, Michael Silverman, M.D., F.R.C.P.C.H.48,52, Peter Sly, M.D., F.R.A.C.P., D.S.48,53, John Tsanakas, M.D., Ph.D.48,54, Andrea Von Berg, M.D.48,55, Moira Whyte, Ph.D., F.R.C.P., F.Med.Sci.48,56, Malcolm Blumenthal, M.D.48,57, Medea Imboden, Ph.D.2,30,31,32,33, Thierry Rochat, M.D.33,58, Gian Andri Thun, M.S.30,31,32,33, Margaret W. Gerbase, M.D., Ph.D.33,58, Ivan Curjuric, M.D.30,31,32,33, Jean-Michel Gaspoz, M.D.33,59, Lee-Jane S. Liu, Sc.D.30,31,33, Inge M. Wouters, Ph.D.2,60,61, Torben Sigsgaard, M.D., Ph.D.2,61,62, Dick Heederik, Ph.D.2,60,61, Ioannis Basinas, M.Sc.60,61,62, Vivi Schlunssen, M.D., Ph.D.61,62, Øyvind Omland, M.D., Ph.D.61,62,63, Paul Cullinan, M.D., Ph.D.1,2,61, Roel Vermeulen, Ph.D.60,61, John Henderson, M.D.2,64,65, Raquel Granell, Ph.D.2,65,66, Wendy L. McArdle, Ph.D.5,65,66, George Davey Smith, M.D.65,66,67, Alan L. James, M.D., F.R.A.C.P.2, 68,69,70, Jennie Hui, Ph.D.70,71, Lyle J. Palmer, Ph.D.2, 70,72, John Beilby, Ph.D., F.A.C.B.70,73, A.William Musk, Ph.D., F.R.A.C.P.2,70,74,75, Catherine Laprise, Ph.D.2,76,77,78, Thomas J. Hudson, M.D.2,78,79, Mathieu Lemire, Ph.D.78,79, Denise Daley, Ph.D.2,80,81, Allan Becker, M.D.81,82, Moira Chan-Yeung, M.D.81,83, Andrew  Sandford, Ph.D.80,81, Anita L. Kozyrskyj, Ph.D.81,82,84,85, Peter Paré, M.D.2,80,81, Alexander Ferguson, M.D.81,86, Helen Dimich-Ward, Ph.D.81,83, Wade T. Watson, M.D.81,82, Maxim B. Freidin, Ph.D.2,87,88, Elena Iu. Bragina, Ph.D.87,88, Ivan A. Deev, M.D., Ph.D.88,89, Eugenia V. Deeva, M.D., Ph.D.88,89, Olga S. Kobyakova, M.D., Ph.D.88,90, Valery P. Puzyrev, M.D., Ph.D.2,87,88, Ludmila M. Ogorodova, M.D., Ph.D.2,88,89, Elza K. Khusnutdinova, Ph.D.2,91,92, Alexandra S. Karunas, M.D., Ph.D.2,91,92, Yuliya Y. Fedorova, Ph.D.91,92, Ian P. Hall, D.M., F.R.C.P.93,94, Ian Sayers, B.Sc., Ph.D. 93,94, Martin D. Tobin, Ph.D. 94,95, F.F.P.H., Yize I. Wan, B.MedSci. 93,94, Liam G. Heaney, M.D., M.R.C.P. 94,96, Basima A.H. Al-Momani, B.Sc., M.Sc. 94,97, Adel H. Mansur, Ph.D., F.R.C.P. 94,98, Sarah Manney, Ph.D. 94,98, Neil C. Thomson,  M.D. 94,99, Rekha Chaudhuri, M.D. 94,99, Christopher E. Brightling, Ph.D., M.R.C.P. 2,94,100,101, Mona Bafadhel, M.B.Ch.B.94,100,101, Amisha Singapuri, B.Sc.94,100,101, Robert Niven, M.D.  F.R.C.P.94,102, Angela Simpson, M.D., Ph.D.94,102, John W. Holloway, B.Sc., Ph.D 94,103,  Peter H. Howarth, D.M., F.R.C.P.94,103,104, Alexey V. Polonikov, M.D., Ph.D.2,105,106, Vladimir P. Ivanov, M.D., Ph.D.105,106, Maria A. Solodilova, Ph.D.105,106, Erik Melén, M.D., Ph.D.2,107,108,109, Göran Pershagen, M.D., Ph. D.2,107,109, Anna Bergström, Ph.D.107,109, Inger Kull, Ph.D.107,109, Fredrik Nyberg, M.D., Ph.D.107,109,110,  Magnus Wickman, M.D., Ph.D.107,109,111, Cilla Söderhäll, Ph.D.109,112,  Juha Kere, M.D., Ph.D.109,112, Dirkje S. Postma, M.D., Ph.D.2,113,114, Marjan Kerkhof, M.D., Ph.D.114,115, Bert Brunekreef, Ph.D.60,114,116, Henriette A. Smit, Ph.D.114,116, Johan C. de Jongste, M.D., Ph.D.114,117, Alet Wijga, Ph.D.114,118, R. C. Aalberse, Ph.D.114,119, Maarten O. Hoekstra, M.D., Ph.D.114,120, Gerard H. Koppelman, M.D., Ph.D.2,114,121, Aristea Binia, M.Sc.1,101, Kian Fan Chung, M.D., D.Sc.1,2,101,122, Pankaj Bhavsar, Ph.D.1,101, Florence Chow, R.N.2,101,122, Patricia Macedo, M.B.B.S.1,101,122, Andrew Menzies-Gow, M.B.B.S., Ph.D.1,101,122, Nicole van Stiphout, R.S.C.N., R.N2,101,123, Andrew Bush, M.D., F.R.C.P., F.R.C.P.C.H.1,2,101,123, Young-Ae Lee, M.D.2,124,125,126, Jorge Esparza-Gordillo, Ph.D.124,125,126, Renate Nickel, M.D.124,126, Ulrich Wahn, M.D.124,126, Susanne Lau, M.D.124,126, Ingo Marenholz, Ph.D.124,125,126, Tari Haahtela, M.D., Ph.D.2,127,128, Leena von Hertzen, Ph.D.2,127,128, Pekka Jousilahti, M.D., Ph.D.128,129, Tiina Laatikainen, M.D., Ph.D.128,129, Mika J. Mäkelä, M.D., Ph.D.127,128, Erkki Vartiainen, M.D., Ph.D.128,129, Tarja Laitinen, M.D., Ph.D.2,128,130, David J. Balding, B.Math., D.Phil.2,131, John F. Peden, Ph.D.2,10, Eve Corda, M.Sc.4,5,7, Doris Lechner, Dipl.3, Cèline Besse, D.E.S.S. 3, Diana Zelenika, Ph.D.3, Anne Boland, Ph.D. 3, Delphine Bacq, M.Sc.3, Stephanie Demonchy, M.Sc. 3, Helene Blanche, Ph.D.5, Yoichiro Kamatani, M.D., Ph.D.5, Erika von Mutius, M.D., M.Sc.2,42,132, Martin Farrall, F.R.C.Path.2,10, Mark Lathrop, Ph.D. 2,3,5, William O.C.M. Cookson, M.D., D.Phil1,2.

* Equal first authors

  • 1National Heart and Lung Institute, Imperial College, London, UK
  • 2Member of the GABRIEL Consortium
  • 3Commissariat à L’Energie Atomique, Institut de Génomique, Centre National de Génotypage, Evry, France
  • 4Inserm, Unité 946, Fondation Jean-Dausset- Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France
  • 5Fondation Jean Dausset-CEPH, Paris, France
  • 6Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France
  • 7Epidemiological study on the Genetics and Environment of Asthma (EGEA) Investigator
  • 8Division of Community Health Sciences, St George’s, University of London, UK
  • 9British 1958 Birth Cohort (B58C) Investigator
  • 10Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
  • 11Respiratory Epidemiology and Public Health, Imperial College, London, UK
  • 12European Community Respiratory Health Survey (ECRHS) Investigator
  • 13Institute of Lung Biology and Disease, Helmholtz Zentrum, Munich, Germany
  • 14German Research Centre for Environmental Health (GmbH), Neuherberg, Germany
  • 15Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  • 16Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain
  • 17CIBER Epidemiologia y Salud Pública (CIBERESP), Spain
  • 18National School of Public Health, Athens, Greece
  • 19Tartu University Hospital, Lung Clinic, Tartu, Estonia
  • 20Respiratory Medicine and Allergology, University of Uppsala, Uppsala, Sweden
  • 21Department of Surgery, Umeå University, Umeå, Sweden
  • 22Institute of Medicine, University of Bergen, Bergen, Norway
  • 23Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
  • 24Inserm, Unité 700, Paris, France
  • 25Université Paris Diderot, Paris, France
  • 26Centre Hospitalier Universitaire, Grenoble, France
  • 27Inserm, Unité 823, Grenoble, France
  • 28Université Joseph Fourier, Grenoble, France
  • 29Helmholtz Zentrum Munich Institute of Epidemiology, Munich, Germany
  • 30Swiss Tropical and Public Health Institute, Basel, Switzerland
  • 31University of Basel, Basel, Switzerland
  • 32Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zürich, Switzerland
  • 33Swiss study on Air Pollution and Lung Disease In Adults (SAPALDIA) Investigator
  • 34Departament de Ciències Experimentals i de la Salut,  Universitat Pompeu Fabra (UPF), Barcelona, Spain
  • 35Servicio de Neumología, Hospital Juan Ramón Jiménez, Huelva, Spain
  • 36Servicio de Neumología, Hospital General Universitario de Albacete, Albacete, Spain
  • 37Pneumology Service, Galdakao Hospital, Galdakao, Bizkaia, Spain
  • 38Servicio de Neumología, Hospital General de Asturias, Oviedo, Asturias, Spain
  • 39Inserm, Unité 780, Villejuif, France
  • 40Université Paris-Sud, IFR69, Villejuif, France
  • 411st Department of Paediatrics, Allergology and Cardiology, Wroclaw Medical University, Poland
  • 42GABRIEL Advanced Surveys (GABRIEL AS) Investigator
  • 43Institute of Epidemiology, Ulm University, Germany
  • 44Department of Preventive Dentistry and Periodontology and Department of Medicine II - Grosshadern, University of Munich, Germany
  • 45Department of Pediatrics, Pediatric Pulmonology, Innsbruck Medical University, Austria
  • 46Centre for Paediatrics and Adolescent Medicine, Clinic for Paediatric Pneumology and Neonatology, Hannover Medical School, Germany
  • 47Genetics, GlaxoSmithKline R & D, Research Triangle Park, NC, USA (current address Pharmaceutical Exploratory Development, Roche Pharmaceuticals, Nutley, NJ, USA)
  • 48Genetics of Asthma International Network (GAIN) Investigator
  • 49University of Aberdeen, Royal Aberdeen Children’s Hospital, Aberdeen, UK
  • 50Department of Paediatrics, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
  • 51Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
  • 52Division of Child Health, University of Leicester, Leicester, UK
  • 53Centre for Child Health Research, University of Western Australia, Perth, Western Australia
  • 54Pediatric Pulmonology, Aristotle University of Thessaloniki, Greece
  • 55Abt. Fuer Kinderheilkunde Foschungsinstitut zur Praevention von Allergien und Atemwegserkrankungen im Kindesalter, Wesel, Germany
  • 56Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield, UK
  • 57Department of Medicine, University of Minnesota, MN. USA (Progenitor Collection)
  • 58Division of Pulmonary Medicine, University Hospitals of Geneva, Switzerland
  • 59Division of Community Medicine and Primary Care, University Hospitals of Geneva, Switzerland
  • 60Institute for Risk Assessment Sciences (IRAS), University of Utrecht, Utrecht, the Netherlands
  • 61Industrial Cohorts Research Group Investigator
  • 62Department of Environmental and Occupational Medicine, School of Public Health, University of Aarhus, Bartolin Allé 2, Building 1260, 8000  Aarhus C, Denmark
  • 63Aalborg Hospital, Aarhus University Hospital, Department of Occupational Health, Havrevangen 1, 9000 Aalborg, Denmark
  • 64Department of Community-based Medicine, University of Bristol, Bristol, UK
  • 65Avon Longitudinal Study of Parents and Children (ALSPAC) Investigator
  • 66School of Social and Community Medicine, University of Bristol, Bristol, UK
  • 67MRC Centre for Causal Analysis in Translational Epidemiology (CAiTE), University of Bristol, Bristol, UK
  • 68West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Western Australia
  • 69School of Medicine and Pharmacology, University of Western Australia, Western Australia
  • 70The Busselton Health Study (BUSSELTON) Investigator
  • 71Molecular Genetics, PathWest Laboratory Medicine, Western Australia
  • 72Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Western Australia
  • 73Biochemistry, PathWest Laboratory Medicine, Western Australia
  • 74Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Western Australia
  • 75School of Population Health, University of Western Australia, Western Australia
  • 76Community Genomic Medicine Centre, University of Montreal, Chicoutimi University Hospital, Chicoutimi, Canada
  • 77Université due Québec à Chicoutimi, Chicoutimi, Canada
  • 78Saguenay-Lac-Saint-Jean (SLSJ) Familial Collection Investigator
  • 79Ontario Institute for Cancer Research, Toronto, Canada
  • 80James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada
  • 81Canadian Childhood Cohorts: Canadian Asthma Primary Prevention Study (CAPPS) & Study of Asthma Genes and Environment (SAGE) Investigator
  • 82Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  • 83Occupational and Environmental Lung Disease Unit, University of British Colombia, Vancouver, BC, Canada
  • 84Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada
  • 85Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
  • 86Division of Allergy, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
  • 87Population Genetics Laboratory, Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, 634050 Tomsk, Russian Federation
  • 88TOMSK Study Investigator
  • 89Department of Faculty Paediatrics, Siberian State Medical University, 634050 Tomsk, Russian Federation
  • 90General Doctor Practice Department, Siberian State Medical University, 634050 Tomsk, Russian Federation
  • 91Institute of Biochemistry and Genetics, UFA Scientific Centre, Russian Academy of Sciences, 450054, Ufa, Prospect Oktyabrya 71
  • 92UFA Study Investigator
  • 93Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, Queen’s Medical Centre, Nottingham, UK
  • 94AUGOSA Study Investigator
  • 95Department of Health Sciences, University of Leicester, Leicester, UK
  • 96Respiratory Medicine, Queen’s University of Belfast, Belfast, Northern Ireland UK
  • 97School of Pharmacy, Queen’s University of Belfast, Belfast, Northern Ireland UK
  • 98Respiratory Medicine, Birmingham Heartlands Hospital and University of Birmingham, Birmingham, UK
  • 99Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow UK
  • 100Institute for Lung Health, University of Leicester, Glenfield  Hospital, Leicester, UK
  • 101SEVERE ASTHMA COHORTS Investigator
  • 102The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, Manchester, UK
  • 103Division of Human Genetics and Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, UK
  • 104Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton School of Medicine, Southampton, UK
  • 105Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russian Federation
  • 106KSMU Study Investigator
  • 107Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • 108Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
  • 109BAMSE Study Investigator
  • 110AstraZeneca, R&D Mölndal, Mölndal, Sweden
  • 111Sachs Children’s Hospital, Stockholm, Sweden
  • 112Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
  • 113Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
  • 114PIAMA Study Investigator
  • 115Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
  • 116Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands
  • 117Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands
  • 118Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
  • 119Sanquin Research, Department of Immunopathology, Amsterdam, the Netherlands
  • 120Department of General Paediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
  • 121Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands
  • 122Royal Brompton Hospital, London UK
  • 123Department of Paediatric Respiratory Medicine, Royal Brompton Hospital
  • 124Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany
  • 125Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin-Buch, Germany
  • 126The German Multicenter Allergy Study (MAS) Investigator
  • 127Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
  • 128KARELIA Allergy Study (KARELIA) Investigator
  • 129National Institute for Health and Welfare, Helsinki, Finland
  • 130Department of Pulmonary Medicine, Helsinki University Central Hospital, Helsinki, Finland
  • 131Department of Epidemiology and Public Health, Imperial College, London, UK
  • 132University Children’s Hospital, Asthma and Allergy Department, Ludwig Maximilians University, D80337 Munich, Germany.